Tested it on themselves first, sometimes more than once.

He inoculated himself with a patient's discharge to settle a scientific question, and his reputation was so enormous that nobody checked his work for fifty-one years.

He built a small closet, filled it with the vomit of the dying, and sat inside breathing deeply — all to prove yellow fever wasn't contagious.

He inherited 132,000 acres at age two and died in a debtors' prison at thirty-seven, and those are not the strange parts.

He discovered oxygen two years before the man history credits with discovering oxygen.

He described hydrogen cyanide as having a 'pleasantly sharp acidulous flavor,' the way someone else might describe a good Riesling.

He boiled 1,500 gallons of urine looking for gold and accidentally discovered the first new element since antiquity.

After nearly walking into Lake Michigan in 1927, Buckminster Fuller decided instead to document his entire life in fifteen-minute intervals.